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Biomarkers/Epidemiology/Outcomes

Gastrointestinal (Colorectal) Cancer

2019 ASCO Annual Meeting

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ABSTRACT TITLEFIRST AUTHORABSTRACT NO.
3D in vitro system for measuring treatment responses to immunotherapy in CRC patients.

Andreas Block

e15114

A plasma-only integrated genomic and epigenomic circulating tumor DNA (ctDNA) assay to inform recurrence risk in colorectal cancer (CRC).

Aparna Raj Parikh

3602

A pooled analysis of multicenter cohort studies of post-surgery circulating tumor DNA (ctDNA) in early stage colorectal cancer (CRC).

Jeanne Tie

3518

An evaluation of RAS testing and survival among mCRC patients in the United States.

Enko Kiprilov

e15144

An improved method for detection of methylated circulating tumor DNA in colorectal cancer.

Nicky Boulter

e15120

Analytical and clinical validation of a novel amplicon-based NGS assay for evaluation of circulating tumor DNA in metastatic colorectal cancer patients.

Beili Wang

e15084

Association between pretreatment Fusobacterium nucleatum and cancer pain at six months postsurgery in newly diagnosed colorectal cancer patients: Results from the ColoCare Study.

Anita Roselyn Peoples

3581

Association between primary tumor site, perioperative CEA ratio, smoking status, and overall survival in patients with colorectal cancer.

Thomas A Odeny

e15156

Association of PIK3CA mutations (mut) with immune engagement and clinical benefit from immunotherapy in microsatellite stable (MSS) colorectal cancer (CRC) patients (pts).

Maliha Nusrat

3604

Association of colon cancer (CC) molecular signatures with prognosis and oxaliplatin prediction-benefit in the MOSAIC Trial (Multicenter International Study of Oxaliplatin/5FU-LV in the Adjuvant Treatment of Colon Cancer).

Katherine L. Pogue-Geile

3503

Association of MAPK signaling subtypes with prognostic benefit for bevacizumab in left-sided metastatic colorectal cancer (mCRC) patients treated with FOLFIRI + cetuximab / bevacizumab (FIRE-3 trial).

Arndt Stahler

3584

Association of microRNA-21 with efficacy of cetuximab in RAS wild-type patients in the FIRE-3 study (AIO KRK-0306) and microRNA-21’s influence on gene expression in the EGFR signaling pathway.

Lisa Miller-Phillips

3593

Association of TGF-β expression with intratumoral infiltration of cytotoxic T lymphocytes in patients with microsatellite-stable colorectal cancer.

Amir Mehrvarz Sarshekeh

3577

B7-H3 expression by immunohistochemistry as a negative prognostic biomarker in colorectal carcinoma (CRC) in a racially diverse population.

Meghan Kaumaya

e15127

Characteristics of colorectal patients who discontinued oxaliplatin therapy.

Alexander Buchholz

e15155

Chemotherapy-induced neuronal dysfunction in the absence of axon degeneration.

Stephen Nick Housley

e15091

Clinical verification of circulating tumor RNA (ctRNA) as novel pretreatment predictor and tool for quantitative monitoring of treatment response in metastatic colorectal cancer (mCRC): A biomarker study of the DEEPER trial.

Yu Sunakawa

TPS3621

Clinicopathological description of a subset of schistosoma mansoni associated colorectal cancer patients in an endemic area in Brazil.

Gustavo Fernandes Godoy Almeida

e15154

Clonal hematopoiesis mutations in plasma cfDNA RAS/BRAF genotyping of metastatic colorectal cancer.

Beili Wang

e15083

Colorectal cancer in young patients: An institutional experience.

Wissam Hanayneh

e15140

Colorectal cancer molecular subtypes by immunohistochemistry in a patient cohort from Nigeria.

F Biade Abdulkareem

e15145

Combination of tissues analysis and immune infiltrate in localized colon cancer using artificial intelligence in PETACC8 study.

Cynthia Reichling

3574

Comparison of HER2 overexpression with total Her2 mutation on resistance of EGFR-targeted therapy in Ras wild-type mCRC patients.

Wenju Chang

3594

Completion of adjuvant chemotherapy with Cape/CAPOX in colon cancer: A retrospective database study.

Edward Chu

e15116

Comprehensive immune transcriptomic subtypes of colorectal cancer for development of precision immunotherapy.

Zhou Jing

e15078

Correlation of peripheral blood markers of DNA damage and immune response with chemoradiation response in patients with locally advanced rectal cancer.

Sanjeevani Arora

e15109

Defining an IBD-like subgroup in consensus molecular subgroups of colorectal cancer and transcriptomic biomarker development for at-risk patients.

Enya Scanlon

e15142

Detection of KRAS mutations in colon adenocarcinoma by droplet digital PCR.

Yaroslav S. Enin

e15080

Differences in clinical outcomes in young-onset colorectal cancer based on ethnicity in an NCI designated comprehensive cancer center.

Benjamin David Fangman

3605

Differences in pathology and mutational status among colorectal cancer (CRC) patients pre-, post-, and during screening age.

Gustavo Dos Santos Fernandes

3596

Dissection of the lateral lymph nodes with short axis of ≥ 5 mm affects the prognosis in rectal cancer patients: A central review of 738 lower rectal cancer magnetic resonance images.

Koya Hida

3578

Distance from the anal verge as an indirect measure to predict response to anti-EGFR therapy in left side metastatic colon cancer.

Daniela Pezzutti DOMINGUES Armentano

e15153

DNA methylation profiling from circulating tumor DNA for early-detection of colorectal cancer.

Wei Zhang

e15076

Effect of JAG2 on migration and invasion in colorectal cancer cell by PRAF2, independent of epithelial-mesenchymal transition.

Wan He

e15107

Effect of PTPRB on metastasis of colorectal carcinoma and induction of epithelial-mesenchymal transition.

Xingyue Weng

e15099

Evaluating cancer outcomes of outpatient colonoscopies in elderly patients older than 85 years of age.

Joy A Lee

e15079

Exosomal markers (CD63 and CD9) expression using immunohistochemistry (IHC) in patients with right-sided and left-sided colon cancer.

Pranitha Prodduturvar

e15119

Exosomes derived miR-454-3P to promote the progression of colorectal cancer via MIER1-mediated Notch signaling activation.

Dawei Li

e15108

Exploring the genetic basis of Lynch-like syndrome through paired germline and tumor exome sequencing.

Jason Willis

3592

Frequency of somatic mutations in the KRAS gene in patients of the South Russia diagnosed with colorectal cancer.

Dmitry Yu. Gvaldin

e15081

Gender differences in prognostic value of immune-related biomarkers in colon cancer patients randomized to surgery or surgery and adjuvant chemotherapy treatment.

Lisa Villabona

3603

Gene expression and genetic variants in Parkinson's disease (PD) genes to predict outcome in metastatic colorectal cancer (mCRC): Data from FIRE-3 phase III trial.

Francesca Battaglin

3595

Gene mutations of SWI/SNF complex and molecular profile in colorectal cancer.

Ryuma Tokunaga

3600

Genetic characteristics of lung metastasis and liver metastasis from left-sided colorectal cancer with microsatellite stability.

Zhenghang Wang

e15097

Germline multigene panel testing in colorectal cancer: Precision therapy and clinical management implications.

Edward D. Esplin

3582

High incidence of advanced stage cancer and prolonged rectal bleeding history before diagnosis in young-onset patients with colorectal cancer.

Gurprataap Singh Sandhu

3576

Histological growth pattern as a potential marker of oligometastatic disease in patients operated for colorectal liver metastases.

Ali Bohlok

e15093

Identifying anti-EGFR (EGFRi) response subgroups using evidence of ctDNA selective pressure.

Christine Megerdichian Parseghian

3587

IGF-1 and IL-6 as predictors of sarcopenia in non-metastatic colorectal cancer patients.

Karam Khaddour

e15150

Immune-related gene signature in predicting prognosis of early-stage colorectal cancer patients.

Jia Ke

3586

Incidence of venous thromboembolic disease (VTE) in a cohort of patients with colorectal cancer (CRC) according to KRAS, NRAS and BRAF status.

Pilar Garcia-Alfonso

e15136

Influence of WNT and DNA damage response pathway alterations on outcomes in patients with unresectable metastatic colorectal cancer.

Sebastian Mondaca

3585

Is the predictive and prognostic impact of sporadic and familial microsatellite instable stage III colon cancer different? A pooled analysis of the PETACC8 and NCCTG N0147 (Alliance) trials.

Aziz Zaanan

3583

KLF4 p.A472D mutation: An acquired resistant mutation to cetuximab in colorectal cancer.

Liu Yang

e15077

KRAS mutation and microsatellite instability in colorectal cancer: Screening pattern and mutational landscape across the US.

Johannes Uhlig

e15138

Long non-coding RNA Linc00525 as a prognostic factor to regulate proliferation and apoptosis in colorectal cancer.

Peng Peng

e15085

Machine learning for CT texture analysis in chemosensitivity of colorectal liver metastases: Initial results.

Yuji Miyamoto

e15148

Meat consumption and BRAF mutation status in colorectal cancer.

Rosa L. Frias

e15135

Metastatic pattern and tumor sidedness in colorectal cancer.

Mahvish Muzaffar

e15147

Methylated DNA markers (MDMs) in primary (pCRC) and metastatic colorectal cancers (mCRC).

Hao Xie

3599

Microsatellite instability status in metastatic colorectal cancer and effect of immune checkpoint inhibitors on survival in MSI-high metastatic colorectal cancer.

Wataru Okamoto

e15106

Molecular analysis of advanced colorectal cancer in a patient cohort of Hispanics, African Americans, and Caucasians within a diverse single institution.

Nadia Ashai

e15121

Molecular landscape of colorectal cancers harboring R-spondin fusions.

Andreas Seeber

3588

Mutation profiling of BRAF gene in Chinese patients with early or advanced colorectal cancer using comprehensive NGS panel.

Canfeng Lin

e15124

Mutational signatures of early-onset colorectal cancer.

Silvia Marsoni

e15113

Optimizing cut-offs for high neutrophil-to-lymphocyte ratio as poor survival prognostic factor in colorectal cancer.

Fernando Namuche

e15111

Pattern of expression of CDX2 in colorectal cancer and its role in prognosis.

JAGDEEP SINGH

e15115

Performance comparison of the methylated BCAT1/IKZF1 ctDNA test (COLVERA) with the CEA assay for detection of recurrent colorectal cancer.

Erin L. Symonds

3589

Population-based screening for BRAF V600E in metastatic colorectal cancer (mCRC) to reveal true prognosis.

Jenny E. Chu

3579

Prediction model for detecting circulating tumor DNA (ctDNA) in metastatic colorectal cancer (mCRC).

Allan Andresson Lima Pereira

3590

Prediction of trifluridine/tipiracil (TAS-102) effectiveness in patients with refractory metastatic colorectal cancer (mCRC): Real-life data from the Czech Republic.

Peter Grell

e15102

Preoperative platelet leukocyte ratio as an independent risk factor for postoperative outcomes in colorectal cancers.

Carrie E Ryan

3591

Prevalence of DNA damage response and repair, cellular signaling, tumor suppressor, and immune checkpoint gene mutations in gastrointestinal cancers.

Aidan M Burke

e15149

Prognosis and chemosensitivity of non-V600E BRAF mutations in metastatic colorectal carcinoma (mCRC): An AGEO French multicenter retrospective cohort.

Aline Derosiere

3575

Prognostic impact of mutation profiling in Chinese patients with colorectal liver metastases.

Kun Wang

e15157

Prognostic stromal and immune response expression patterns in early-stage colorectal cancer predicted by genes intrinsically expressed by tumor epithelial cells.

Pratyaksha Wirapati

3601

Prognostic value of circulating cytokines in colorectal cancer: A prospective study in sixty colorectal cancer patients in Tunisia.

Jihene Braham Ayari

e15130

Prospective assessment of the risk for colorectal neoplasia in a Mexican population according to risk categories.

Vanessa Rosas Camargo

e15158

Racial disparities in clinico-pathological features and survival rates of early-onset colorectal cancer.

Ana Acuna Villaorduna

e15089

Radiomic profiles via machine learning to predict response, overall survival, and KRAS status in metastatic colorectal tumors treated with FOLFOX/bevacizumab/hydroxychloroquine.

Saima Rathore

e15125

Radiomics features on CT scans to predict response to HER2-targeted therapy of hepatic metastases from colorectal cancer.

Valentina Giannini

e15086

RAS analysis of circulating tumor cells from advanced colorectal cancer using BEAMing technology.

Santiago Cabezas-Camarero

e15151

RAS mutations in patients with metastatic colorectal cancer in Central America and the Caribbean.

Luis Garcia-Aceituno

e15126

Rates of genotyping for KRAS, NRAS, BRAF, microsatellite instability (MSI), and mismatch repair (MMR) in metastatic colon cancer patients: Gaps and implications.

Martin Gutierrez

e15123

Real-world study of cetuximab used every other week versus weekly in US patients with metastatic colorectal cancer (mCRC).

Francois-Xavier Lamy

e15087

Relative contribution of clinical and molecular features to outcome within low and high risk T and N groups in stage III colon cancer (CC).

Frank A. Sinicrope

3520

Retrospective analysis of overall survival (OS) by subsequent therapy in patients (pts) with RAS wild-type (wt) metastatic colorectal cancer (mCRC) receiving irinotecan ± cetuximab in the EPIC study.

Alberto F. Sobrero

3580

Risk of treatment-related death in carriers of pathogenic DPYD polymorphisms treated with fluoropyrimidine chemotherapy: A systematic review and patient-level analysis.

Karan Rai

e15132

Sensitive detection of microsatellite instability in tumors and liquid biopsies using nuclease-based enrichment.

Ioannis Ladas

e15117

Simultaneous resection of colorectal cancer with synchronous liver metastases: A survey-based analysis.

Pablo Emilio Serrano Aybar

e15073

Single center experience: Management of metastatic appendiceal cancer with peritoneal carcinomatosis.

Sindhu Janarthanam Malapati

e15103

Spatial heterogeneity of KRAS mutations in colorectal cancers: A population-based study in northern France.

Anne Ploquin

e15101

Structured literature review (SLR) and meta-analyses of the prevalence of microsatellite instability high (MSI-H) and deficient mismatch repair (dMMR) in gastric, colorectal, and esophageal cancers.

Mayur Amonkar

e15074

The 55 STAR study: Prognostic and predictive value of the 55-gene classifier (55GC) in stage III colon cancer.

Toshiaki Ishikawa

3597

The association between female hormonal supplementation and molecular types in colorectal cancer.

Seung Won Chung

e15133

The Idylla MSI Test (CE-IVD) multi-center concordance study: Microsatellite instability detection in colorectal cancer samples.

Patrick Pauwels

e15112

The metabolic clinical risk score (mCRS) as a new prognostic model for surgical decision in patients with colorectal liver metastases.

Ivan Duran Derijckere

e15094

The mutational landscape of circulating cell-free DNA to identify neoadjuvant chemotherapy response in colorectal cancer patients.

Yanlong Liu

e15096

The mutational landscape of MSI-H and MSS colorectal cancer.

Enxiao LI

e15122

The mutational profile analysis of extramural vascular invasion in rectal cancer.

Mingtian Wei

e15128

The prognostic value of KRAS mutation in locally advanced rectal cancer.

Veli Bakalov

e15090

The results of 3000 Fit: A prospective study led at Saint Joseph University of Beirut.

Ronaldo Elkaddoum

e15141

The study of the significance and prognosis of the differential expressed miRNAs and their target genes associated with biological in colorectal cancer.

Mingyun Wang

e15088

Toxicity of chemotherapy in patients with colorectal cancer: The role of age in the Latin American setting.

Fernando Namuche

e15095

Tumor stroma percentage (TSP) and intrinsic subtypes in stage II/III colon cancer: NRG Oncology/NSABP C-07 trial.

Rim S Kim

e15075

Turning on the lights in gastrointestinal oncology: How digital medicines reveal clinical insights on medication adherence and patient behaviors.

Paul Morales

e15118

Urban/rural disparities in stage at presentation of colorectal cancer among young adults in the United States, 2007-2015.

Victoria Nguyen

3598

Utility of effect size to define populations with durable clinical outcomes across trials of metastatic colorectal cancer.

Jeremy D. Kratz

e15104