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Cancer Genetics

Cancer Prevention, Hereditary Genetics, and Epidemiology

2019 ASCO Annual Meeting

Sort by: title abstract no. first author
ABSTRACT TITLEFIRST AUTHORABSTRACT NO.
A multi-institutional investigation assessing prevalence of germline genetic alterations in Chinese patients with gastric carcinoma.

Yinjie Zhang

e13020

A new method towards calculating the cancer cell fraction in cell-free DNA.

Tiancheng Han

e13053

A novel computational tool for copy number variation detection in targeted circulating tumor DNA.

Jianing Yu

e13051

A phase II study of PD-1 inhibition for the prevention of colon adenomas in patients with Lynch syndrome and a history of partial colectomy.

Joanne M. Jeter

TPS1587

Adequacy of self-reported family history in electronic health record for genetic risk assessment for Lynch syndrome.

Mala Pande

1515

Alteration of TGF-β signaling pathway predicts worse prognosis in pancreatic ductal adenocarcinoma.

Bole Tian

e13006

An EGFR extracellular domain mutation data in the East Asian non-small cell lung cancer populations and response to icotinib: A multicenter study.

Wen xian Wang

e13000

Analysis of mutation detection in cell-free DNA in ascites using comprehensive NGS panel.

Chunmei Shi

e13029

Association of polybromo-associated baf (PBAF) complex mutations with overall survival (OS) in cancer patients (pts) treated with checkpoint inhibitors (ICIs).

Sarah Abou Alaiwi

103

BRCA1/2 germline mutations and response to PARP inhibitor treatment in lung cancer.

Wenfeng Fang

e13007

Breast radiotherapy among ATM-mutation carriers.

Leslie A. Modlin

1504

Characterization and clinical outcomes of mismatch repair deficient (dMMR) small bowel adenocarcinoma (SBA).

Alicia Latham

1511

Characterization of Lynch syndrome (LS) associated cancers in patients with immune dysfunction.

Shahla Bari

1532

Clinical genomic profiling to identify actionable alterations for very early relapsed triple-negative breast cancer patients in Chinese population.

Ruoxi Hong

e13031

Clinical impact of comprehensive versus targeted genomic analysis for precision oncology.

Mario Lamping

e13033

Clinical insights for hematological malignancies from an artificial intelligence decision-support tool.

Miyoung Kim

e13023

Clonal hematopoiesis of indeterminate potential (CHIP) mutations in solid tumor malignancies.

Madison Conces

1507

Comparative analysis of prognostic molecular signatures in Asian and Caucasian AML populations.

Miyoung Kim

e13025

Comparative gene expression analysis in gliomas with different IDH1/2 status.

Natalya N. Timoshkina

e13008

Comprehensive germline panel testing across cancer types: Diagnostic yield and clinical utility in 100,000 patient dataset.

Shan Yang

e13013

Confirmation of germline variants identified by tumor testing: A population-based study.

Alexandra Pender

e13021

Detect and visualize tumor microsatellite instability status from next-generation sequencing data by simulating PCR techniques.

Shifu Chen

e13052

Diagnostic accuracy of the Videssa protein-based liquid biopsy for breast cancer in suspicious mammography.

Cynthia Chen

e13034

Discovering HPV16 and HPV18 infection status and cancer gene variations in cervical cancer patient specimens by using Next-generation sequencing.

Bo Meng

e13040

Discussion on several problems between tumor-associated venous thrombosis and driving genes status.

Xue Zhang

e13022

Effect of germline ATM mutations on clonal hematopoiesis.

Thomas Paul Slavin

1509

Evaluation of next generation sequencing for detecting HER2 copy number in breast and gastric cancers.

Dongmei Lin

e13004

Gaining insights into the DICER1 syndrome: An early report from the Italian DICER1 registry.

Arcangela De Nicolo

1519

Genetic identification and characterization of Lynch syndrome in a multi-ethnic biobank.

Rachel Rosenblum

1520

Genetic predisposition to breast cancer among African American women.

Julie R Palmer

104

Germline EGFR mutation and cancer predisposition in adolescent and young adult (AYA) females with adrenocortical carcinoma.

Sara Akhavanfard

e13014

Germline DNA damage repair gene alterations in Chinese prostate patients: More than HRR and MMR.

Junlong Wu

e13041

Germline mutation PTCH2 1172-1173delCT in Chinese population with early-onset breast cancer.

Lixi Li

e13049

Germline mutations and onset of lung adenocarcinoma in smokers and nonsmokers.

Karen L. Reckamp

1518

Germline variants in urothelial carcinoma: Analysis of pathogenic and likely pathogenic variants in 645 subjects.

Sarah Abou Alaiwi

1528

Gliomas in the context of Li-Fraumeni syndrome: An international cohort.

Orli Michaeli

1517

Improving access to genetic counseling services in an adolescent and young adult (AYA) clinic.

Jessica Ross

e13009

Incidence of FGFR-TACC gene fusions in Chinese non-small cell lung cancer (NSCLC): A multicenter study.

Xiuyu Cai

e13001

Inherited DNA repair and cell cycle gene defects in chronic lymphocytic leukemia.

Nicholas S. Moore

1508

Integrated genomics-based approach to identify new therapeutic targets and cancer biomarkers for lung cancer.

Yataro Daigo

e13019

Landscape of multilocus inherited neoplasia alleles syndrome in China.

Quchang Ouyang

e13027

Low likelihood that potential germline findings identified during somatic tumor testing are evaluated: Room for improvement.

Heather Wright

e13037

Meta-analysis utilizing public data suggests role of innate immunity in the pathogenesis of hurthle cell carcinoma (HCC).

David Allen

e13048

MUC16 germline mutations may predispose inherited cancer family members to lung adenocarcinomas.

Tao Wang

e13039

Mutational analysis of key genes in patients from the Kazakh population with early onset of breast cancer.

Dilyara Kaidarova

e13038

Pathogenic germline mutation hotspots in east Asian cancer genomes.

Xiaoshun Shi

e13011

Pathogenic germline mutation profile in Chinese lung cancers and related-driver mutation pattern.

Wenying Peng

e13003

Predictive molecular tumor response through circulating DNA (cDNA) measurements and correlation with established prognostic markers in a series of solid tumors treated with multitargeted epigenetic therapy (MTET).

Mohammad A. Nezami

e13015

Preimplantation genetic diagnosis: What do BRCA mutation carriers think?

Olivia R Khouri

1526

Prevalence and clinical implications of mismatch repair (MMR) deficiency in unselected non-serous epithelial ovarian cancer (EOC) patients (pts).

Mariana Scaranti

1521

Prevalence and penetrance of breast cancer-associated mutations identified by multiple-gene sequencing in the Women’s Health Initiative.

Allison W. Kurian

1513

Preventive surgery after multiplex genetic panel testing (MGPT).

Gregory Idos

1525

Procancerous immune cells in primary tumor is associated with breast cancer recurrence.

Takashi Takeshita

e13042

Prognosis value of a genetic score based on germline genetic variants in a prospective cohort of early triple-negative breast cancer patients.

Elsa Curtit

1529

Prospective Registry of Multiplex Testing (PROMPT): Follow-up.

Jamie Brower

1527

Racial and ethnic differences in the results of multigene panel testing of inherited cancer predisposition genes in breast cancer patients.

Siddhartha Yadav

1514

Rare tumor with matched germline whole exome sequencing to identify somatic and inherited variants of clinical significance.

Bryce Perkins

1523

RAS activation and CDKN2A deletion to predict prognosis in cancer of unknown primary.

Tilmann Bochtler

e13026

Real-world large-scale study of ERBB2 gene fusions and its response to afatinib in Chinese non-small cell lung cancer (NSCLC): A multicenter study.

Chunwei Xu

e13002

Relative risks of prostate cancer associated with different family cancer histories.

Jennifer Lynn Beebe-Dimmer

1505

Results of NGS panel of hereditary breast and ovarian cancer in Lebanese women.

Joseph Al Ajami

e13045

Risk of cancer in first-degree relatives of childhood cancer patients: A linked longitudinal population-based registry study.

Laura-Maria Madanat-Harjuoja

1522

RNA sequencing analysis for profiling activation of cancer-associated molecular pathways.

Anton Buzdin

e13032

Screening of differentially expressed genes of esophageal squamous cell carcinoma with cDNA microarray.

Si Fuchun

e13005

SeqPlus sequencing methodology enables robust whole-genome sequencing, true variant detection, and novel genomic insights from archival esophageal carcinoma FFPE samples.

Shannon Terrell Bailey

e13016

Test of InheRET, an online tool to facilitate NCCN Guideline compliant referrals for cancer genetic counseling.

Lynn McCain

1530

The landscape of POLE/POLD1 mutations in Chinese solid tumor patients.

Linrong Pang

e13050

The PHACT Study: Population Health and Cancer Testing.

Mallika Sachdev Dhawan

1531

The targetable mutation landscape of Chinese patients with non-small cell lung cancer.

Jun Li

e13018

Tumor mutation burden and PD-L1 expression in SDH/FH mutated solid tumors.

Leylah Drusbosky

1524