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Molecular Diagnostics and Imaging

Developmental Therapeutics and Tumor Biology (Nonimmuno)

2019 ASCO Annual Meeting

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ABSTRACT TITLEFIRST AUTHORABSTRACT NO.
[18F] Fluciclatide PET as a biomarker of clinical response to combination therapy of pazopanib and paclitaxel in patients with platinum-resistant or platinum-refractory advanced ovarian cancer: Results of a phase Ib study.

Rohini Sharma

3070

18F-alfatide PET may predict anti-angiogenic drugs toxicity.

Jie Liu

e14608

A functional measurement of MAPK pathway activation to predict response to MEK inhibitors in RAS-mutated patients.

Shumei Kato

3071

A phase II study for prostate cancer monitoring using 18F-DCFPyL and blood-based biomarkers.

Emerson A. Lim

TPS3154

A preliminary single institution experience with droplet digital polymerase chain reaction (dd-PCR) liquid biopsy (LB) for therapeutic decision in advanced solid tumors: Personal precision oncology clinic and genetic diagnostics, Brazil.

Andre Marcio Murad

e14613

An artificial intelligence approach to variant calling of ALK resistance mutations.

Jochen K Lennerz

3079

Analytical validation of the Oncomine Pan-Cancer Cell-Free Assay in a CLIA- and CAP-regulated laboratory for detection of solid tumor-derived variants in blood plasma.

John B. Williamson

e14614

Antitumor immune response induced by NBTXR3 activated by radiotherapy.

Juliette Thariat

e14609

Automated breast cancer lesion detection on breast MRI using artificial intelligence.

Nataly Tapia Negrete

e14612

Clinical impact of tissue of origin testing and mutation profiling in the Solving Unknown Primary Cancer (SUPER) national prospective study: Experience of the first two years.

Linda R. Mileshkin

3072

Clinical Trial in Progress: The FLEX Big Data Platform explores new gene expression profiles and investigator-initiated protocols in early-stage breast cancer.

Sarah Untch

TPS3155

Comparison of an automated cartridge-based system for mRNA assessment with central immunohistochemistry in the neoadjuvant GeparX trial.

Carsten Denkert

3075

Comparison of diagnostic methodologies to detect chromosomal abnormalities.

Cynthie Wong

e14617

Concurrent targeted resequencing for translocations and mutations in tumor samples.

Li Chen

e14597

Determining clinical relevance of genomic heterogeneity in an ethnically diverse cohort of newly diagnosed patients with breast cancer.

Padma Sheila Rajagopal

3084

Exceptions to the rule: Novel retrospective analysis of a single-center institution of the PSMA PET/CT modality.

Vipal P. Durkal

e14625

Genomic analysis of metastatic solid tumors in veterans: Findings from the VHA National Precision Oncology Program.

Pradeep Poonnen

3074

Highly sensitive detection of rare mutant alleles by combining argonaute-based enrichment and XNA-PCR.

Jinzhao Song

e14605

Image-guided surgery for tumor agnostic detection of solid tumors using the pH-activated micellar imaging agent ONM-100.

Floris Jan Voskuil

3068

Impact of precision medicine on clinical care: A single institution retrospective study.

Rajvi Patel

e14601

Integration of radiomic, genomic and clinical data to support decision making for lung cancer.

Thierry Colin

e14607

Machine learning algorithm analysis using a commercial 592-gene NGS panel to accurately predict tumor lineage for carcinoma of unknown primary (CUP).

Jim Abraham

3083

Mapping the activation landscape of the MAPK\ERK pathway for variants of unknown significance (VUS) using convolutional neural networks (CNN).

Gabi Tarcic

e14615

MET kinase domain rearrangements across 10 cancer types.

Jun Zhao

3078

Muscle wasting, visceral and subcutaneous adiposity, inflammation, nutritional deficiencies, and metastatic esophageal cancer (MEC) prognosis.

Jaspreet K Bajwa

e14595

No-cost next generation sequencing of advanced cancer patients within the Strata Precision Oncology Network supports clinical trial enrollment.

Marc Ryan Matrana

3073

Noninvasive prediction of future macrovascular invasion occurrence in hepatocellular carcinoma based on quantitative imaging analysis: A multi-center study.

JingWei Wei

e14623

Notch family gene mutations associate with high tumor mutational burden in diverse cancers.

Da Jiang

e14616

Observational, multicenter, prospective study to assess the impact on patients' outcome of a systematic screening of oncogenic drivers in advanced cancer: The GETHI XX-16 study.

Carmen Beato

3082

Prediction of lesion shrinkage using CT imaging with radiomic and deep learning approaches.

Junshui Ma

e14592

Proteomic profile of high-risk luminal A early breast cancers.

Nawale Hajjaji

3077

Quantitative image profiling of the tumor microenvironment on double stained immunohistochemistry images using deep learning.

Mate Levente Nagy

e14619

Radiomics features to identify distinct subtypes of triple-negative breast cancers.

Haruka Itakura

3069

Real-world experience in advanced NSCLC using FDA approved NGS CDx.

Ehab Elkhouly

e14602

Relationship of MET exon 14 splicing variants and MET exon 14 skipping expression in NSCLC FFPE samples.

John B. Williamson

e14603

Role of radiomics to differentiate benign from malignant pheochromocytomas and paragangliomas on contrast enhanced CT scans.

Bahar Laderian

e14596

The ACC melanoma pilot project: “Real-world” evaluation of an NGS platform for molecular characterization of melanoma in Italy.

Ivan Molineris

e14600

The landscape of ARID1A variants and correlation with tumor mutational burden in Chinese solid tumor patients.

Jia Wei

e14624

Transcriptome-based cancer type prediction for tumors of unknown origin.

Jack Michuda

3081

Tumor volumetric correlation with plasma cell free DNA (cfDNA) mutation detection in metastatic lung cancers.

Justin Haseltine

e14610

Utility of somatic mutation panel testing in patients with advanced cancer receiving treatment in an Irish teaching hospital.

Hadia Khan

3076

Validation and utilization of NGS based HEMEaccuTest panel and analysis software for hematological malignancies.

Hyun-Jeung Choi

e14606

Whole transcriptome sequencing in metastatic cancer: A review of expression outliers in 113 metastatic breast cancer patients.

Nathalie LeVasseur

3080