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Attend this session at the
2019 ASCO Annual Meeting!


Session: Gastrointestinal (Colorectal) Cancer

Type: Poster Session

Time: Monday June 3, 8:00 AM to 11:00 AM

Location: Hall A

Circulating tumor DNA dynamics, serial testing and evolution on treatment in 322 colorectal cancer patients.

Sub-category:
Advanced Disease

Category:
Gastrointestinal (Colorectal) Cancer

Meeting:
2019 ASCO Annual Meeting

Abstract No:
3566

Poster Board Number:
Poster Session (Board #58)

Citation:
J Clin Oncol 37, 2019 (suppl; abstr 3566)

Author(s): Pashtoon Murtaza Kasi, Saivaishnavi Kamatham, Dorin Colibaseanu, Amit Merchea, Faisal Shahjehan, Jason Scott Starr, Kabir Mody; Mayo Clinic, Jacksonville, FL; University of Florida Health Cancer Center, Jacksonville, FL

Abstract Disclosures

Abstract:

Background: According to the American Society of Clinical Oncology and College of American Pathologists (ASCO/CAP) joint review on circulating tumor DNA (ctDNA) issued in March 2018, widespread use of ctDNA assays in most patients with advanced cancer is still an area of ongoing research. However, multiple studies thereafter published and/or presented support its use in patients with metastatic colorectal cancer (CRC). This has led to several institutions adopting it as ‘clinical practice’. The aim of this study is to report on our institution’s adoption of ctDNA testing for every patient at the time of diagnosis and/or time of progression. Methods: We report on results of 322 CRC patients with 607 ctDNA tests at our center from January 2017 to February 2019 using a commercially available platform (Guardant360). Results: Among 322 patients of our cohort, a total of 607 ctDNA tests were done (Table). 127 (39.4%) of these tests were serial analyses. In the CRC patients who had serial testing, at progression, mechanisms of resistance included acquisition of KRAS, NRAS, EGFR mutations; and HER2- and MET-amplifications. The subclonal mutations were noted to disappear when the selective inhibition was stopped. This was seen in patients on targeted therapies/biologics rather than chemotherapy. This was of value in treatment modification, clinical trial selection and/or monitoring of disease progression in these patients. Conclusions: While ctDNA testing may not be ready for primetime in all advanced cancers, it is increasingly being adopted in practice for especially metastatic CRC. Of particular value is the serial ctDNA testing in the RAS/RAF wildtype subset and now BRAF V600E mutant CRC on anti-EGFR based therapies.

Total number of patients322
Total number of tests607
Number of serial analyses127
RAS/RAF wild-type214 (66.4%)
Number of RAS mutations83 (25.8%)
Number of V600E BRAF mutations18 (5.6%)
Number of non-V600EBRAF mutations7 (2.2%)
Number of HER2 amplifications13 (4%)
Number of HER2 mutations7 (2.2%)
MSI-High*3 (1%)

*Of note, 25(7.8%) of CRC were dMMR/MSI-High in the cohort. CtDNA testing company started reporting MSI-High later in 3rd quarter of 2018.

 
Other Abstracts in this Sub-Category:

 

1. Randomized phase III study comparing FOLFOX + bevacizumab versus folfoxiri + bevacizumab (BEV) as 1st line treatment in patients with metastatic colorectal cancer (mCRC) with ≥3 baseline circulating tumor cells (bCTCs).

Meeting: 2019 ASCO Annual Meeting Abstract No: 3507 First Author: Javier Sastre
Category: Gastrointestinal (Colorectal) Cancer - Advanced Disease

 

2. Updated results of TRIBE2, a phase III, randomized strategy study by GONO in the first- and second-line treatment of unresectable mCRC.

Meeting: 2019 ASCO Annual Meeting Abstract No: 3508 First Author: Chiara Cremolini
Category: Gastrointestinal (Colorectal) Cancer - Advanced Disease

 

3. A randomized phase II trial of second-line CAPTEM versus FOLFIRI in MGMT methylated, RAS mutated metastatic colorectal cancer (mCRC) patients.

Meeting: 2019 ASCO Annual Meeting Abstract No: 3509 First Author: Filippo Pietrantonio
Category: Gastrointestinal (Colorectal) Cancer - Advanced Disease

 

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