Best of ASCO - 2014 Annual Meeting



Publication-only abstracts (abstract number preceded by an "e"), published in conjunction with the 2019 ASCO Annual Meeting but not presented at the Meeting, can be found online only.

iMETX (Individualized Metabolic RX): An environmental intervention to increase energy expenditure in breast cancer survivors.

Health Promotion

Symptoms and Survivorship

2019 ASCO Annual Meeting

Abstract No:

J Clin Oncol 37, 2019 (suppl; abstr e23060)

Author(s): Tarah Jean Ballinger, Sandra K. Althouse, Timothy P. Olsen, Kathy Miller, Jeffrey Sledge; Indiana University, Indianapolis, IN; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN; University of Wisconsin, Madison, WI; University of Wisconsin Department of Landscape Planning and Architecture, Madison, WI

Abstract Disclosures


Background: Despite survival and quality of life benefits associated with physical activity (PA), many breast cancer survivors remain inactive. Effective, sustainable PA interventions must account for individual differences in capability, motivation, and environment. iMETX evaluated the feasibility, mechanics, and efficacy of delivering an individualized, dynamic intervention to increase energetic capacity and energy expenditure in breast cancer survivors. Methods: Stage 0-III breast cancer pts who had completed primary treatment were enrolled. Baseline PA patterns were collected using a wearable GPS/accelerometer for 4 weeks pre- intervention. Detailed movement data collection continued throughout the 12- week intervention, during which pts received tailored PA “prescriptions” every 1-3 days from an interactive web application, adjusted based on individual capability and environment to achieve pre- determined energy endpoints. Baseline and post- intervention, energetic capacity was assessed by power generation using a stationary bicycle protocol feasible in the clinic setting over a range of physical capabilities. Body composition by DEXA and quality of life questionnaires were collected. Results: 56 of 57 enrolled pts completed the intervention (98%). Median age was 60 (range 38 – 82), and pts were an average of 5.25 yrs from diagnosis (range 0.5 – 21 yrs). In the total population, energetic capacity (Watts/kg lean mass) increased significantly from 1.75 to 1.99 W/kg (p < 0.01) post- intervention. Separated by baseline energetic capacity, the lowest performing tertile improved significantly (0.76 to 1.12 W/kg, p < 0.01), while the highest performing tertile did not (2.75 to 2.96 W/kg, p = 0.30). Physical and functional well-being also improved (FACT-B TOI, pre: 72.26, post: 74.66, p = 0.02). Conclusions: iMETx is a feasible PA intervention with high adherence rates. Individualized PA prescriptions allowing pts to move in their typical environment resulted in improved energetic capacity and well- being. Results were particularly significant in those with the lowest baseline energetic capacity, a population most in need of effective and accessible PA interventions. Clinical trial information: NCT03158519

Other Abstracts in this Sub-Category:


1. Effects of a structured intervention program to improve physical activity (PA) of adolescents and young adult cancer survivors (AYAs): Final results of the randomized Motivate AYA–MAYA trial.

Meeting: 2019 ASCO Annual Meeting Abstract No: 11518 First Author: Jannike Lisa Salchow
Category: Symptoms and Survivorship - Health Promotion


2. Association of obesity with breast cancer outcome in relation to cancer subtypes.

Meeting: 2019 ASCO Annual Meeting Abstract No: 11557 First Author: Ana Elisa Lohmann
Category: Symptoms and Survivorship - Health Promotion


3. Physiological and psychosocial effects of a highly structured exercise program on breast cancer survivorship.

Meeting: 2019 ASCO Annual Meeting Abstract No: 11558 First Author: Judy A. Tjoe
Category: Symptoms and Survivorship - Health Promotion