Best of ASCO - 2014 Annual Meeting



Attend this session at the
2019 ASCO Annual Meeting!

Session: Symptoms and Survivorship

Type: Poster Session

Time: Monday June 3, 1:15 PM to 4:15 PM

Location: Hall A

Physiological and psychosocial effects of a highly structured exercise program on breast cancer survivorship.

Health Promotion

Symptoms and Survivorship

2019 ASCO Annual Meeting

Abstract No:

Poster Board Number:
Poster Session (Board #250)

J Clin Oncol 37, 2019 (suppl; abstr 11558)

Author(s): Judy A. Tjoe, Linda B. Piacentine, Jun Yin, Paula Papanek, Alexander V. Ng; TORQUE, Aurora Health Care/ECOG/ACRIN, Milwaukee, WI; Marquette University College of Nursing, Milwaukee, WI; Aurora Research Institute, Milwaukee, WI; Marquette University, Milwaukee, WI; Marquette University College of Health Sciences, Milwaukee, WI

Abstract Disclosures


Background: Exercise after breast cancer treatment improves cancer-related outcomes, although the mechanism of action is unclear. Engagement in healthy active lifestyles after cancer treatment may also impact overall survival. We aimed to determine effectiveness of a highly structured, clinically overseen, goal oriented, group triathlon training program on improving physiological and psychosocial outcomes in female breast cancer survivors (BCS). Methods: After stage appropriate local and systemic breast cancer treatment, 53 female BCS were recruited to participate in this study. The 14-week group triathlon training program was individually adjusted for treatment side effects. 28 similar BCS who did not participate in the training served as controls. Pre- and post-exercise training measures included: Functional endurance (Timed 6MWT), quality of life (QOL, FACT-B), cancer-related fatigue (CRF, FACIT-F), exercise self-efficacy (ESE) via questionnaires, estradiol, and inflammatory biomarkers (C-reactive protein, TNFr1, leptin and adiponectin). Results: Complete data were obtained from 41 [mean age 51 (7) yr, mean BMI 29.5 (6.2)] triathlon finishers and 16 [mean age 56 (10) yr, mean BMI 31.5 (8.0)] controls. 6MWT improved (26 m) more in the triathlon group (p < 0.05). FACT-B, FACIT-F, and ESE all improved compared to controls (all p < 0.05). Body mass and BMI decreased in the training group compared to controls (p = 0.01, p = 0.04 respectively). Arm circumference decreased in the trained group but increased in controls (p < 0.05). Estradiol and leptin positively correlated with initial body weight in both groups but did not change after training. Adiponectin significantly decreased in the triathlon group (p = 0.01), perhaps due to selection bias of controls. No significant changes were seen in other serological markers. Conclusions: A highly structured, clinically overseen, moderate intensity exercise program can improve endurance, QOL, CRF, body mass, and possibly improve survival after breast cancer treatment. Furthermore, improvements in ESE may provide tools for patients to continue adherence to regular exercise guidelines that may lower obesity and its related comorbidities, including arm lymphedema.

Other Abstracts in this Sub-Category:


1. Effects of a structured intervention program to improve physical activity (PA) of adolescents and young adult cancer survivors (AYAs): Final results of the randomized Motivate AYA–MAYA trial.

Meeting: 2019 ASCO Annual Meeting Abstract No: 11518 First Author: Jannike Lisa Salchow
Category: Symptoms and Survivorship - Health Promotion


2. Association of obesity with breast cancer outcome in relation to cancer subtypes.

Meeting: 2019 ASCO Annual Meeting Abstract No: 11557 First Author: Ana Elisa Lohmann
Category: Symptoms and Survivorship - Health Promotion


3. Tobacco retail availability and tobacco cessation in lung and head and neck (HN) cancer survivors.

Meeting: 2019 ASCO Annual Meeting Abstract No: 11559 First Author: Lawson Eng
Category: Symptoms and Survivorship - Health Promotion