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Attend this session at the
2019 ASCO Annual Meeting!


Session: Symptoms and Survivorship

Type: Poster Session

Time: Monday June 3, 1:15 PM to 4:15 PM

Location: Hall A

A randomized trial of a healthy lifestyle intervention versus usual care on chemotherapy and endocrine therapy adherence rate in women with breast cancer: The Lifestyle Exercise and Nutrition Early After Diagnosis (LEANER) Study.

Sub-category:
Health Promotion

Category:
Symptoms and Survivorship

Meeting:
2019 ASCO Annual Meeting

Abstract No:
TPS11633

Poster Board Number:
Poster Session (Board #323a)

Citation:
J Clin Oncol 37, 2019 (suppl; abstr TPS11633)

Author(s): Tara B. Sanft, Maura Harrigan, Brenda Cartmel, Leah M. Ferrucci, Karen Basen-Engquist, Dawn L. Hershman, Jennifer A. Ligibel, Marian Neuhouser, Anees B. Chagpar, Beth A. Jones, M. Tish Knobf, Andrea Silber, Fangyong Li, Melinda L. Irwin; Yale School of Medicine, New Haven, CT; Yale School of Public Health, New Haven, CT; Yale University School of Public Health, New Haven, CT; The University of Texas MD Anderson Cancer Center, Houston, TX; Columbia University Medical Center, New York, NY; Dana-Farber Cancer Institute, Boston, MA; Fred Hutchison Cancer Center, Seattle, WA; Yale Cancer Center, New Haven, CT; Yale, New Haven, CT; Yale Univ School Nursing, Orange, CT; Yale Center for Analytical Sciences, New Haven, CT

Abstract Disclosures

Abstract:

Background: The World Cancer Research Fund and the American Cancer Society provide diet and exercise guidelines for cancer survivors. Many women with breast cancer do not follow these guidelines. Adoption of recommended lifestyle behaviors soon after diagnosis may prevent adverse changes in body composition, breast cancer biomarkers, and may improve adherence to treatment thereby improving breast cancer prognosis. The Lifestyle, Exercise, and Nutrition Early after Diagnosis (LEANER) study is testing the impact of a healthy lifestyle intervention on chemotherapy completion and endocrine therapy adherence. Secondary endpoints include changes in inflammatory and metabolic biomarkers, body composition, and patient reported outcomes. Methods: Eligible participants are women with stage I-III breast cancer undergoing chemotherapy. 250 participants are being recruited and randomized 1:1 to a yearlong, 16 session, healthy diet and exercise counseling intervention or usual care group. The intervention is delivered in person and/or via telephone by registered dietitians with training in exercise science. Materials include workbooks, videos, cookbooks, fit bits, and home-based exercise equipment. Intervention is focused on graduated goal setting to meet the recommended diet and exercise guidelines for cancer survivors. The primary endpoint, chemotherapy completion rate, is gathered from the Electronic Medical Record and the average Relative Dose Intensity for the originally planned regimen is calculated based on standard formulas. Assessments are completed at baseline, post chemotherapy, 1- and 2- year time points (to assess adherence to endocrine therapy). Body composition is measured using dual energy X-ray absorptiometry, blood samples and patient reported outcomes are collected. At time of submission, 39 women have been randomized. Discussion: If successful, this study has the potential to make healthy lifestyle interventions initiated shortly after diagnosis a standard component of breast cancer treatment. Clinical trial information: NCT03314688

 
Other Abstracts in this Sub-Category:

 

1. Effects of a structured intervention program to improve physical activity (PA) of adolescents and young adult cancer survivors (AYAs): Final results of the randomized Motivate AYA–MAYA trial.

Meeting: 2019 ASCO Annual Meeting Abstract No: 11518 First Author: Jannike Lisa Salchow
Category: Symptoms and Survivorship - Health Promotion

 

2. Association of obesity with breast cancer outcome in relation to cancer subtypes.

Meeting: 2019 ASCO Annual Meeting Abstract No: 11557 First Author: Ana Elisa Lohmann
Category: Symptoms and Survivorship - Health Promotion

 

3. Physiological and psychosocial effects of a highly structured exercise program on breast cancer survivorship.

Meeting: 2019 ASCO Annual Meeting Abstract No: 11558 First Author: Judy A. Tjoe
Category: Symptoms and Survivorship - Health Promotion

 

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