Publication-only abstracts (abstract number preceded by an "e"), published in conjunction with the 2019 ASCO Annual Meeting but not presented at the Meeting, can be found online only.
Third and successive–lines of chemotherapy in NSCLC patients without therapeutic targets: Experience of the Grupo Gallego de Cáncer de Pulmón.
Metastatic Non-Small Cell Lung Cancer
Lung Cancer—Non-Small Cell Metastatic
2019 ASCO Annual Meeting
J Clin Oncol 37, 2019 (suppl; abstr e20579)
Author(s): Francisco Javier Afonso Afonso, Natalia Fernández Núñez, Rocio Vilchez Simo, Jose-luis Firvida, Noemi De Dios Alvarez, Begoña Campos Balea, Juan Ruiz Bañobre, Maria Carmen Areses Manrique, Sara Agraso Busto, Marta Carmona Campos, Laura María De Paz Árias, Soledad Cameselle Garcia, Diego Pereiro Corbacho, Sergio Vázquez Estévez, Jesús García Mata, Joaquin Casal Rubio, Manuel Constenla; Complejo Hospitalario Universitario de Ferrol, Ferrol a Coruna, Spain; Hospital Universitario Lucus Augusti, Lugo, Spain; Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain; Complejo Hospitalario Universitario de Ourense, Orense, Spain; Complejo Hospitalario Universitario de Vigo, Vigo, Spain; Complejo Hospitalario Universitario de Ferrol, Ferrol, Spain; Complejo Hospitalario Universitario de Ourense, Ourense, Spain; Servicio de Oncología Médica, Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Spain
Background: The current treatment of advanced non-small cell lung cancer (NSCLC) is conditioned by the presence of molecular and immunohistochemical biomarkers. In the absence of these, the therapeutic option is the use of chemotherapy with or without antiangiogenic agents. The efficacy of non-target systemic treatments is not proven, beyond a second-line and the experiences in their use are limited to retrospective analyzes. We present the experience of the Grupo Gallego de Cáncer de Pulmón in patients with advanced NSCLC treated exclusively with three or more lines of chemotherapy. Methods: Retrospective analysis of patients with advanced NSCLC, treated with three or more lines of chemotherapy in standard regimen, with or without antiangiogenic agents, in Galicia´s hospitals, Spain. Results: We included 168 patients (134 male and 34 female) treated with three or more chemotherapy lines, with a median age at the time of receiving the first-line, of 60.84 years (41-83). Of these, 51 (30,35%) received a fourth-line and 18 (10,74%) a fifth-line of treatment. None received antitarget therapy or immunotherapy. The median overall survival (OS) was 18.1 months. The median OS after the third line was 6.1 months, with 73% of patients alive at three months and 44% six months after the start of that therapeutic line. We did not appreciate differences in OS between those who received three lines and those who received the largest number of subsequent treatments. Our multivariate analysis (age, gender, histology, performance status at initiation of each teatment-line, response to previous treatments) identified that the individuals who benefited the most were those under the age of 60 years, PS-ECOG 0-1 at diagnosis and those with a more durable response to the first-line. Conclusions: The third-line of chemotherapy can benefit those patients with advanced NSCLC, under 60 years of age at the time of diagnosis, with good performance status and with long-lasting responses to the first line of treatment. We did not see benefit in adding fourth or fifth-line of chemotherapy. All data will be presented in the 2019 ASCO annual meeting.