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Cancer Genetics

Cancer Prevention, Hereditary Genetics, and Epidemiology

2018 ASCO Annual Meeting

Sort by: title abstract no. first author
ABSTRACT TITLEFIRST AUTHORABSTRACT NO.
"What if I keep my breasts?" Extended follow-up of unaffected BRCA mutation carriers diagnosed with breast cancer (BC) in the Toronto magnetic resonance imaging (MRI) screening study.

Ellen Warner

1523

MET gene fusions in non-small cell lung cancer (NSCLC) in the Chinese population: A multicenter study.

Wen xian Wang

e13539

Analysis of hereditary cancer syndromes in patients from the United Arab Emirates.

Shaheenah S. Dawood

e13509

Analysis of the copy-number variation in the BRCA1 gene in patients with breast cancer in northwest of Mexico.

Edith Eunice Garcia Alvarez

e13502

Association analysis of the combination of tumor burden and PD-L1 expression and response to PD-1/L1 inhibitors in Chinese cancer patients.

Kunsong Li

e13520

Beyond BRCA1 and BRCA2: Implementation of a multigene panel for the upfront testing of germline mutations in ovarian cancer.

Maria Beatriz Mira

1542

BRCA1/BRCA2 predictive genetic testing in an Irish population: A missed opportunity.

David Edward O Reilly

e13530

Cancer driver genes in luminal and triple negative breast cancer from young women.

Simone Maistro

e13527

Clinical factors associated with urinary tract cancers (UTCs) among Lynch syndrome (LS) patients (Pts).

Jonathan W. Wischhusen

1517

Colorectal cancer risk in Li-Fraumeni syndrome: Is it time for earlier surveillance?

Suzanne Macfarland

e13503

Comparison of clinicopathological (CP) features and outcome of breast cancers (BC) in BRCA-mutation carriers patients, with a family history without BRCA-mutation and with sporadic disease.

Stephanie Becourt

e13522

Compliance with high-risk screening of unaffected BRCA1 and BRCA2 pathogenic variant carriers.

Wendy Salinas Brouwer

e13528

Comprehensive genetic analysis of microsatellite instability-high colorectal cancers.

Kazuhito Sato

e13536

Comprehensive genomic profiling in Chinese patients with clear cell renal cell carcinoma.

Baiye Jin

e13517

Correlation between genetic mutation state and cancer-associated thrombosis in advanced cancer patients.

Da Jiang

e13524

Count me in: A patient-driven research initiative to accelerate cancer research.

Nikhil Wagle

e13501

CYP2D6 polymorphism in Chinese breast cancer population.

Kai Li

e13529

Development of HOPE-Genomics: An IT platform for patient-directed cancer genome sequencing education and return of results.

Ilana Solomon

1532

Differences between screen-detected and interval breast cancers among BRCA mutation carriers.

Melissa Louise Pilewskie

1529

DNA damage repair (DDR) germline mutations in patients (Pts) with urothelial carcinoma (UC).

Maria Isabel Carlo

1516

Effect of breastfeeding on the risk of breast cancer in Li-Fraumeni syndrome.

Payal Khincha

1530

Evaluating empowerment in genetic counseling using patient reported outcomes.

Suat Ying Lee

1547

Evaluation of whole body MRI for early detection of cancer in TP53 mutation carriers: Final results of the LIFSCREEN study.

Olivier Caron

1527

Expanding BRCA1/2 testing criteria to include other confirmed breast and ovarian cancer susceptibility genes.

Fergus Couch

1524

Feasibility of perioperative multi-gene panel testing (MGPT) in cancer patients eligible for hereditary genetic evaluation (GE): The PROTECT pilot.

Michael J. Hall

1536

Frequency of BRCA1 and BRCA2 germline mutations in uterine serous carcinomas and uterine carcinosarcomas.

Deanna Gerber

e13521

Frequent germline BRCA1/2 mutations in women with ovarian cancer and the need for insurance coverage of genetic testing: A Hellenic Society of Medical Oncology (HeSMO) national program.

Georgios Lypas

e13525

Genetic counseling (GC) and germline (GL) testing rates after adoption of an integrated clinical cancer genetics (CCG) approach to genomics tumor board (GTB).

Stefan Klek

1511

Genetic testing and clinical management practices for variants in non-BRCA1/2 breast (and/or ovarian) cancer susceptibility genes: An international survey by the Enigma Clinical Working Group.

Sarah Nielsen

1539

Genomic profiling of Chinese pancreatic adenocarcinoma and the implications for therapy.

Songzhu Yang

e13515

Genomic profiling of tumors from patients with germline BRCA mutations.

Anne-Vibeke Laenkholm

1533

Germline variants of BAP1 in the Australian population.

Sebastian Walpole

e13534

High-quality whole-genome sequencing of FFPE samples.

Shannon Terrell Bailey

e13500

Identification and characterization of germline pathogenic variants using matched tumor-normal next-generation sequencing in 7363 pan-cancer patients in China.

Yuting Yi

1545

Identification and referral of women at risk for BRCA mutations.

Cecelia Bellcross

1514

Importance of genetic counseling referrals for high-risk women with endometrial cancer despite intact mismatch repair immunohistochemistry.

Jessica Lee

1537

Inherited defects in checkpoint kinase 2 (CHEK2) to confer increased susceptibility to testicular germ cell tumors.

Saud H. Aldubayan

1515

Inherited mutations in breast cancer patients with and without multiple primary cancers.

Kara Noelle Maxwell

1503

Integrative clinical genomics of early-onset breast cancer.

Lixi Li

1541

Interest in and outcomes with web-based education for return of genetic research results for inherited susceptibility to breast cancer.

Angela R. Bradbury

1531

Investigation of PIK3CA gene mutation in Indian breast cancer and its correlation with clinicopathological findings.

Simi Bhatia

e13512

Investigation of discordant sibling pairs from hereditary breast cancer (HBC) families.

Kara Landry

1538

Long-term (7-year) outcomes of universal mismatch repair screening (uMMR) of 1156 colorectal (CRC) and endometrial cancers (EC) in an academic setting.

Michael J. Hall

1513

Missed opportunities: Oncologists and palliative care specialists may be the last chance to explore hereditary cancer among cancer in-patients before information and DNA is lost.

Mohammed Abusamaan

e13505

Multi-clonal mutation signatures in primary breast malignancies and their axillary lymph node metastases.

Jiaqi Liu

e13526

Non-BRCA hereditary gene mutations and breast cancer phenotype: An ISC-RAM Consortia study.

Banu Arun

1540

Pan-cancer genomic variation characteristics of CDKN2A/CDKN2B/CCND1 in Chinese patients.

Songfeng Yu

e13519

Pathogenic somatic mutation (SM) of mismatch repair (MMR) genes and associations with microsatellite instability (MSI), tumor mutational burden (TMB) and SM in other DNA repair pathways in 24,223 tumor genomic profiles.

Joseph Nicholas Bodor

1505

Physician survey on utilization of clinical cancer genetics services at an academic institution.

Danielle Krol

e13507

Polygenic risk score for breast cancer in high-risk women.

Mary Helen Black

1508

Population health and cancer testing pilot protocol (PHACT).

Mallika Sachdev Dhawan

1546

Preference for risk reducing surgery among BRCA1/2 mutation carriers in an Asian tertiary cancer center.

Samuel Guan Wei Ow

e13535

Prevalence of EGFR gene fusions in a large cohort of Chinese patients with non-small cell lung cancer (NSCLC).

Chunwei Xu

e13538

Prospective Registry of Multiplex Testing (PROMPT): Feasible and sustainable.

Heather Symecko

1543

Real-world data in clinically non-small cell lung cancer (NSCLC) with Chinese population harboring BRAF gene fusions: A multicenter study.

Jin-huo Lai

e13537

Reliable diagnosis of BRCA1/2 germline mutations from tumor testing using a next-generation sequencing (NGS) platform.

Pei-Yi Ong

e13531

Risk of pediatric malignancy in families known to carry BRCA1/2 mutations.

Kevin Thomas Nead

1535

The effect of Genetic Cancer Risk Assessment (GCRA) on the uptake of risk-reducing surgeries (RRS) in Hispanic women with breast cancer (BC).

Yanin Chavarri Guerra

1548

The prevalence of germline mutations in Chinese colorectal cancer patients with mismatch repair deficiency.

Ying Yuan

e13518

The relationship between serum level of copper and ceruloplasmin and pathologic and clinical characteristics in early breast cancer patients.

Jing Fan

e13504

Therapeutic yield of an NGS pan-cancer panel utilizing joint AMP/ASCO/CAP classification guidelines.

Gregory Lewis

e13513

Towards personalised risk assessment and clinical management: A worldwide study of age-, sex-, geographic region-, gene- and cancer-specific risks for Lynch syndrome.

Aung K. Win

1526

Treatment failure: Why patients with BRCA mutations are declining risk-reducing surgery.

Olivia R Khouri

1544

Tumor suppressor gene and mismatch repair protein expression in uterine sarcomas and carcinosarcomas.

Sally Markee

e13516