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2018 ASCO Annual Meeting!


Session: Health Services Research, Clinical Informatics, and Quality of Care

Type: Poster Session

Time: Saturday June 2, 1:15 PM to 4:45 PM

Location: Hall A

A randomized, controlled trial to assess a multi-level intervention to improve adherence to oral cancer medications.

Sub-category:
Disparities/Access to Care

Category:
Health Services Research, Clinical Informatics, and Quality of Care

Meeting:
2018 ASCO Annual Meeting

Abstract No:
TPS6621

Poster Board Number:
Poster Session (Board #446a)

Citation:
J Clin Oncol 36, 2018 (suppl; abstr TPS6621)

Author(s): Rashmika Potdar, Sneha Karki, Claudia M. Dourado, Kamran Mohiuddin, Djeneba Audrey Djibo, John Charles Leighton, Jean G Ford; Einstein Medical Center Philadelphia, Newtown Square, PA; Einstein Medical Center Philadelphia, Philadelphia, PA; Albert Eisntein Medical Center, Blue Bell, PA; Einstein Medical Center, Philadelphia, PA; Albert Einstein Heathcare Network, Philadelphia, PA

Abstract Disclosures

Abstract:

Background: Cancer treatment with oral cancer medication is complex. Cancer patients require substantial skills to adhere to- and achieve the goals of therapy. Medication adherence among cancer patients is increasingly important, as treatment with oral medications is increasingly prevalent. The rates of adherence to oral therapy vary widely by population, cancer type, and level of education. To date, however, there is no clear evidence on the effect of improvements in health literacy on patients’ adherence to oral cancer medications. We hypothesize that compared to usual care, the addition of a multilevel intervention will result in greater adherence to oral cancer medications. Methods: In a single-center, patients are randomized 1:1 to receive usual care, including clinical care plus education by a registered nurse (Arm 1), or the addition of a multilevel intervention (Arm 2). The multilevel intervention includes a brief web-based educational video on cancer and oral cancer drugs, periodic reinforcement of educational messages with videos, brief phone calls 24 hours and 2 weeks after each encounter, and offer of facilitative services, if needed. Health literacy is recorded at baseline, using REALM R. Adult cancer patients on any oral cancer medication are eligible to participate in the study. Exclusion criteria include ECOG ≥3, concurrent chemo-radiation, hormonal therapy, non-adherence (defined as history of missing 2 or more Oncology clinic appointments), pregnancy, residence in a nursing home, dementia, or lacking decisional capacity. The primary outcome of interest is medication adherence, indicated by the proportion of expected refills completed for oral cancer medications during the follow up period. Secondary outcomes include adherence to follow up visits, adherence to other prescribed medications, healthcare utilization, and other healthcare outcomes. With a one-sided alpha = 0.05, the target sample size of 110 patients, would yield 90% power to test the primary hypothesis. To date, we have randomized 19 participants, and enrollment proceeds as planned. Clinical trial information: NCT03245411

 
Other Abstracts in this Sub-Category:

 

1. Potential life-years lost: The impact of the cancer drug regulatory process in Canada.

Meeting: 2018 ASCO Annual Meeting Abstract No: 6515 First Author: Joanna Gotfrit
Category: Health Services Research, Clinical Informatics, and Quality of Care - Disparities/Access to Care

 

2. The influence of socioeconomic status, tumor characteristics and patterns of breast cancer care on breast cancer specific survival among elderly women.

Meeting: 2018 ASCO Annual Meeting Abstract No: 6557 First Author: Amanda L. Kong
Category: Health Services Research, Clinical Informatics, and Quality of Care - Disparities/Access to Care

 

3. Feasibility of a self-funded model to provide breast cancer services to uninsured women in New York City.

Meeting: 2018 ASCO Annual Meeting Abstract No: 6558 First Author: Janice Zaballero
Category: Health Services Research, Clinical Informatics, and Quality of Care - Disparities/Access to Care

 

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