Best of ASCO - 2014 Annual Meeting

 

Welcome

Publication-only abstracts (abstract number preceded by an "e"), published in conjunction with the 2018 ASCO Annual Meeting but not presented at the Meeting, can be found online only.

Effect of pretreatment steroids on the development of immune related adverse events.

Sub-category:
Immune Checkpoint Inhibitors

Category:
Developmental Therapeutics—Immunotherapy

Meeting:
2018 ASCO Annual Meeting

Abstract No:
e15095

Citation:
J Clin Oncol 36, 2018 (suppl; abstr e15095)

Author(s): Philip Margiotta, Mario Caldararo, Daniel Altman, Sheel A. Patel, Sharon Li, Sean Clark-Garvey, Reetu Mukherji, Thomas Holden, Jennifer Maria Johnson, Marlana M. Orloff, Ryan Michael Weight; Thomas Jefferson University, Philadelphia, PA; Thomas Jefferson University, Philadelphia, PA, US; Thomas Jefferson University, Department of Medical Oncology, Philadelphia, PA; Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA

Abstract Disclosures

Abstract:

Background: Immune checkpoint blockade is being used with increasing frequency across a variety of tumor types. Corticosteroids are used in diverse clinical scenarios and can have immune-modulatory effects. The administration of steroids with immune checkpoint blockade in combination with cytotoxic chemotherapy has not diminished treatment efficacy in select patient populations1. However, the effect of steroids on the development of immune-related adverse events (irAEs) across tumor types is unknown. We hypothesized that pretreatment with corticosteroids reduces treatment-limiting irAEs. Methods: A single institution registry of patients (n = 163) receiving immune checkpoint blockade, including anti-CTLA-4 antibody (n = 51) or anti-PD-1 antibody (n = 112), was reviewed. Various primary tumor types were included (33% melanoma, 31% non-small cell lung, 36% other). Patients were determined to have discontinued treatment because of irAEs versus any other cause (disease progression, infection, comorbidity, or death). Results: None of the 17 patients (0%) who were receiving corticosteroids prior to starting immunotherapy experienced treatment-limiting irAEs (average dose 34mg/day prednisone or equivalent, only one patient taking < 10mg/day prednisone). This is compared to 29 of 146 patients (19.9%) who were not taking steroids at the start of treatment (p = 0.045). Interestingly, pretreatment steroids were not associated with an increase in disease progression or death. Conclusions: Incidence of treatment-limiting immune-related adverse events was significantly decreased, regardless of tumor type, in patients receiving corticosteroids prior to initiation of immunotherapy. An associated decrease in treatment efficacy was not seen.

Incidence of treatment-limiting adverse events in patients undergoing immunotherapy

Treatment-Limiting Adverse Events - n (%)
ImmuneInfection or ComorbidityDisease Progression or DeathOngoing TreatmentTotal
On Steroids When
Immunotherapy Initiated?
Yes0 (0)7 (41.1)8 (47.1)2 (11.8)17 (100)
No29 (19.9)19 (13.0)71 (48.6)27 (18.5)146 (100)
Total29 (17.8)26 (16.0)79 (48.4)29 (17.8)163 (100)

 
Other Abstracts in this Sub-Category:

 

1. ICONIC: Biologic and clinical activity of first in class ICOS agonist antibody JTX-2011 +/- nivolumab (nivo) in patients (pts) with advanced cancers.

Meeting: 2018 ASCO Annual Meeting Abstract No: 3000 First Author: Timothy Anthony Yap
Category: Developmental Therapeutics—Immunotherapy - Immune Checkpoint Inhibitors

 

2. Anti-CD27 agonist antibody varlilumab (varli) with nivolumab (nivo) for colorectal (CRC) and ovarian (OVA) cancer: Phase (Ph) 1/2 clinical trial results.

Meeting: 2018 ASCO Annual Meeting Abstract No: 3001 First Author: Rachel E. Sanborn
Category: Developmental Therapeutics—Immunotherapy - Immune Checkpoint Inhibitors

 

3. NKTR-214 (CD122-biased agonist) plus nivolumab in patients with advanced solid tumors: Preliminary phase 1/2 results of PIVOT.

Meeting: 2018 ASCO Annual Meeting Abstract No: 3006 First Author: Adi Diab
Category: Developmental Therapeutics—Immunotherapy - Immune Checkpoint Inhibitors

 

More...