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Publication-only abstracts (abstract number preceded by an "e"), published in conjunction with the 2018 ASCO Annual Meeting but not presented at the Meeting, can be found online only.

Implications of the 21-gene recurrence score assay (Oncotype DX) on adjuvant treatment decisions in ER-positive early-stage breast cancer patients: Experience of Kuwait Cancer Control Center.

Adjuvant Therapy

Breast Cancer—Local/Regional/Adjuvant

2018 ASCO Annual Meeting

Abstract No:

J Clin Oncol 36, 2018 (suppl; abstr e12582)

Author(s): Mohamed Salah Fayaz, Heba Eissa, Gerges Attia Demian; Hussain Man Juma Center for Speacialised Surgery, Safat, Kuwait; National Cancer Institute, Cairo University, Cairo, Egypt; National Cancer Institute Cairo University, Cairo, Egypt

Abstract Disclosures


Background: To evaluate the impact of Oncotype DX as a tool for adjuvant treatment decision of ER-positive, early stage breast cancer patients diagnosed in Kuwait and to determine which clinicopathological criteria derived the greatest advantage Methods: This retrospective study was designed to review patients with ER-positive, HER2−negative, stage I–IIIA, N0/N1 breast cancer who were tested for Oncotype Dx and treated in Kuwait Cancer Control Center. We used McNemar test to assess the association of Recurrence Score results with the changes in the treatment decisions. Results: Between January 2011 and October 2017, 100 patients at a median age of 50 years (range 38-74 years) were included. The TNM stage distribution was 34, 63 and 3 patients for stage I, II and IIIA respectively. Ki67 was available in 89 patients, 51 had Ki67 ≤ 15% and 38 patients had Ki67 > 15%. Fifty-four patients had Luminal A and 46 had luminal B tumors. The Recurrence Score results were low, intermediate and high risk in 54, 34 and 12 patients respectively. Before the test results, adjuvant chemoendocrine therapy was recommended for 46 patients while 54 were advised for endocrine therapy, according to the multidisciplinary team consensus. After getting the test results, 25 patients received chemoendocrine therapy (1,12 and 12 patients in the low, intermediate and high risk groups respectively) and 75 received endocrine treatment. Treatment change was documented in 37 patients (8 patients from endocrine to chemoendocrine therapy and 29 from chemoendocrine to endocrine treatment; p = 0.001, McNemar test). Treatment change was significant among patients ≤ 50 years (p = 0.002), luminal B tumors (p< 0.0001), stage II&IIIA disease (p < 0.0001) and node positive disease (p = 0.002). At a median follow-up of 12 months (3-75 months), one patient in the low risk group developed systemic relapse. Conclusions: Oncotype DX testing resulted in significant changes in the adjuvant treatment decisions in ER-positive, HER2-negative early breast cancer particularly in the case of young patients, Luminal B tumors, N1 disease and stage II-IIIA disease.

Other Abstracts in this Sub-Category:


1. TAILORx: Phase III trial of chemoendocrine therapy versus endocrine therapy alone in hormone receptor-positive, HER2-negative, node-negative breast cancer and an intermediate prognosis 21-gene recurrence score.

Meeting: 2018 ASCO Annual Meeting Abstract No: LBA1 First Author: Joseph A. Sparano
Category: Breast Cancer—Local/Regional/Adjuvant - Adjuvant Therapy


2. Adjuvant denosumab in early breast cancer: Disease-free survival analysis of 3,425 postmenopausal patients in the ABCSG-18 trial.

Meeting: 2018 ASCO Annual Meeting Abstract No: 500 First Author: Michael Gnant
Category: Breast Cancer—Local/Regional/Adjuvant - Adjuvant Therapy


3. Adjuvant denosumab in early breast cancer: First results from the international multicenter randomized phase III placebo controlled D-CARE study.

Meeting: 2018 ASCO Annual Meeting Abstract No: 501 First Author: Robert E. Coleman
Category: Breast Cancer—Local/Regional/Adjuvant - Adjuvant Therapy