Publication-only abstracts (abstract number preceded by an "e"), published in conjunction with the 2018 ASCO Annual Meeting but not presented at the Meeting, can be found online only.
Study of clinical characteristics of breast cancer among women older than 70 years in a single institute.
2018 ASCO Annual Meeting
J Clin Oncol 36, 2018 (suppl; abstr e12578)
Author(s): Purva Sharma, Elie Donath, Beth Byron, Shachar Peles; University of Miami, Atlantis, FL; University of Miami, Miller School of Medicine, Palm Beach Regional Campus, Atlantis, FL; Florida Cancer Specialists, Atlantis, FL
Background: Breast cancer is the most common type of cancer in women. 35% of breast cancer is reported in women older than 70 years. This study was performed with aim to evaluate the clinical characteristics of breast cancer among women above 70 years. Methods: In this retrospective study, all breast cancer patients diagnosed between 2009 and 2016 at JFK Medical Center were included. All the necessary data about age, race, tumor histopathology, clinical staging, hormone receptor status, type of surgery and type of adjuvant therapy (radiotherapy, chemotherapy, hormone therapy) were extracted from these files. Data was analyzed with SPSS software (version 16). P < 0.05 was considered significant. Results: Out of the 1250 patients, 563(45%) patients were greater than 70 years of age out of which 95% belonged to the Caucasian race. The most common site in this age group was the upper outer quadrant seen in 224 (39.7%) patients. 275 patients presented with Stage 1A (48.8%) which was almost half the number of patients. Those presenting with stage 2A and stage 3A were 112 (20%) and 21 (3.7%) respectively. Most common histology was infiltrating duct carcinoma, seen in 338(60%) patients. The second most common types were the infiltrating duct mixed with other types of carcinoma and intra-ductal carcinoma, non-infiltrating. In terms of hormone receptor status, ER positivity was seen in 492 (87.3%). Similarly, PR positivity was seen in 424 (75.3%). Chemotherapy was used in only 44 patients (8%). Radiation therapy was used in 288 (51%) and 196 (35%) patients were treated with hormonal therapy. Only 8 patients were treated with immunotherapy. Conclusions: The most common type of breast cancer in women above 70 years is infiltrating ductal carcinoma and the most common stage of disease is IA. Most patients are estrogen and progesterone receptor positive. Therefore, it is recommended to pay more attention to their specific clinical characteristics in choosing the treatment approach for this patient population.
1. TAILORx: Phase III trial of chemoendocrine therapy versus endocrine therapy alone in hormone receptor-positive, HER2-negative, node-negative breast cancer and an intermediate prognosis 21-gene recurrence score.