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2018 ASCO Annual Meeting!

Session: Compelling Combinations: Raising the Bar With Immunotherapy

Type: Clinical Science Symposium

Time: Sunday June 3, 9:45 AM to 11:15 AM

Location: Hall D1

Epacadostat (E) plus pembrolizumab (P) versus pembrolizumab alone in patients (pts) with unresectable or metastatic melanoma: Results of the phase 3 ECHO-301/KEYNOTE-252 study.

Advanced Disease

Melanoma/Skin Cancers

2018 ASCO Annual Meeting

Abstract No:

J Clin Oncol 36, 2018 (suppl; abstr 108)

Author(s): Georgina V. Long, Reinhard Dummer, Omid Hamid, Thomas Gajewski, Christian Caglevic, Stéphane Dalle, Ana Arance, Matteo S. Carlino, Jean-Jacques Grob, Tae Min Kim, Lev V. Demidov, Caroline Robert, James M. G. Larkin, James Anderson, Janet E. Maleski, Mark M. Jones, Scott J. Diede, Tara C. Mitchell; Department of Medical Oncology and Translational Research, Melanoma Institute Australia, The University of Sydney, Mater Hospital and Royal North Shore Hospital, Sydney, Australia; University of Zurich Hospital, Department of Dermatology, Zurich, Switzerland; The Angeles Clinic and Research Institute, Los Angeles, CA; University of Chicago Medical Center, Chicago, IL; Instituto Oncologico Fundacion Arturo Lopez Perez, Santiago, Chile; Hospices Civils De Lyon, Pierre-Bénite, France; Hospital, Richmond, United Kingdom; Westmead and Blacktown Hospitals, Melanoma Institute Australia, and The University of Sydney, Sydney, Australia; Dermatology department, CHRU, AP-HM Hôpital de la Timone , Marseille France, Marseille, France; Seoul National University Hospital, Seoul, Korea, Republic of (South); N. N. Blokhin Russian Cancer Research Center, Moscow, Russia; Gustave Roussy Institute, Paris, France; The Royal Marsden Hospital, London, United Kingdom; Merck & Co., Inc., Kenilworth, NJ; Incyte Corporation, Wilmington, DE; Abramson Cancer Center, Philadelphia, PA

Abstract Disclosures


Background: In a phase 1/2 study, the combination of E, a selective oral inhibitor of the IDO1 enzyme, plus P, a PD-1 inhibitor, suggested promising antitumor activity with minimal additive toxicity. ECHO-301/KEYNOTE-252 (NCT02752074) is a phase 3, randomized, double-blind study evaluating the efficacy and safety of E + P vs placebo + P in pts with untreated unresectable or metastatic melanoma. Methods: Pts had histologically confirmed unresectable stage III or IV melanoma and were treatment naive for advanced or metastatic disease, except for pts with the BRAF V600 mutation who could have received prior BRAF/MEK therapy. Pts were stratified by PD-L1 expression and BRAF mutation status (BRAF mutant with prior BRAF-directed therapy, BRAF mutant without prior BRAF-directed therapy, and BRAF wild type) and randomized 1:1 to E 100 mg BID + P 200 mg Q3W or matched E placebo + P 200 mg Q3W. Response was assessed per RECIST v1.1 and irRECIST (both by central review). The primary endpoints were PFS per RECIST v1.1 and OS. Secondary endpoints were ORR per RECIST v1.1, duration of response, and safety. This is the final analysis for PFS and interim analysis for OS. Results: A total of 706 pts were randomized (354 to E + P and 352 to placebo + P); 72.5% of tumors were PD-L1 positive, 44.5% BRAF mutant (12.2% received prior BRAF/MEK therapy). Median follow-up was ~14 mo. E + P did not result in a significantly longer PFS vs placebo + P (median 4.7 vs 4.9 mo; HR=1.00; CI, 0.83-1.21; P=0.517). PFS rate at 12 mo was 37% in both groups. Findings were consistent across PD-L1 and BRAF subgroups. OS was not expected to reach statistical significance based on the results of this interim analysis (HR=1.13; CI, 0.86-1.49; P=0.807). The OS rate at 12 mo was 74% in both groups. ORR was 34.2% and 31.5% in the E + P and placebo + P groups, respectively. Grade ≥3 treatment-related AEs occurred in 21.8% of patients receiving E + P and 17.0% receiving placebo + P. Conclusions: The addition of E to P did not result in greater clinical benefit over P alone in pts with unresectable or metastatic melanoma. The safety profile was consistent with that observed in previously reported studies of this combination. Clinical trial information: NCT02752074

Other Abstracts in this Sub-Category:


1. 4-year survival and outcomes after cessation of pembrolizumab (pembro) after 2-years in patients (pts) with ipilimumab (ipi)-naive advanced melanoma in KEYNOTE-006.

Meeting: 2018 ASCO Annual Meeting Abstract No: 9503 First Author: Georgina V. Long
Category: Melanoma/Skin Cancers - Advanced Disease


2. Overall survival in COLUMBUS: A phase 3 trial of encorafenib (ENCO) plus binimetinib (BINI) vs vemurafenib (VEM) or enco in BRAF-mutant melanoma.

Meeting: 2018 ASCO Annual Meeting Abstract No: 9504 First Author: Reinhard Dummer
Category: Melanoma/Skin Cancers - Advanced Disease


3. Durable tumor regression and overall survival (OS) in patients with advanced Merkel cell carcinoma (aMCC) receiving pembrolizumab as first-line therapy.

Meeting: 2018 ASCO Annual Meeting Abstract No: 9506 First Author: Paul Nghiem
Category: Melanoma/Skin Cancers - Advanced Disease