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2018 ASCO Annual Meeting!

Session: Lung Cancer—Non-Small Cell Metastatic

Type: Oral Abstract Session

Time: Monday June 4, 3:00 PM to 6:00 PM

Location: Hall B1

Overall survival (OS) analysis of IMpower150, a randomized Ph 3 study of atezolizumab (atezo) + chemotherapy (chemo) ± bevacizumab (bev) vs chemo + bev in 1L nonsquamous (NSQ) NSCLC.

Metastatic Non-Small Cell Lung Cancer

Lung Cancer—Non-Small Cell Metastatic

2018 ASCO Annual Meeting

Abstract No:

J Clin Oncol 36, 2018 (suppl; abstr 9002)

Author(s): Mark A. Socinski, Robert M. Jotte, Federico Cappuzzo, Francisco Jorquera Orlandi, Daniil Stroyakovskiy, Naoyuki Nogami, Delvys Rodriguez-Abreu, Denis Moro-Sibilot, Christian A. Thomas, Fabrice Barlesi, Gene Grant Finley, Claudia Kelsch, Anthony Lee, Shelley Coleman, Yijing Shen, Marcin Kowanetz, Ariel Lopez-Chavez, Alan Sandler, Martin Reck; Florida Hospital Cancer Institute, Orlando, FL; Rocky Mountain Cancer Centers, Denver, CO; AUSL Romagna, Ravenna, Italy; Instituto Nacional del Torax, Santiago, Chile; Moscow City Oncology Hospital #62, Moscow, Russian Federation; Department of Thoracic Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan; Hospital Universitavio Insular De Gran Canaria, Las Palmas, Spain; Centre Hospitalier Universitaire de Grenoble, Grenoble, France; New England Cancer Specialists, Scarborough, ME; Hospital Nord Service Oncologie, Marseille, France; Allegheny Health Network Cancer Institute, Pittsburgh, PA; Genentech, Inc., South San Francisco, CA; Genentech, Inc, South San Francisco, CA; LungenClinic Grosshansdorf, German Center for Lung Research, Grosshansdorf, Germany

Abstract Disclosures


Background: Atezo (anti–PD-L1) inhibits PD-L1 to restore anticancer immunity; bev may enhance atezo efficacy by inhibiting VEGF immunosuppression and promoting T-cell tumor infiltration. IMpower150 is the first randomized Ph 3 trial evaluating atezo + chemo (carboplatin [C] + paclitaxel [P]) ± bev vs CP + bev in 1L NSQ NSCLC. PFS benefit was observed with atezo + CP + bev vs CP + bev regardless of PD-L1 expression. Here we present the IMpower150 interim OS results. Methods: 1202 patients (pts) received atezo 1200 mg + C AUC 6 + P 200 mg/m2 (Arm A) or atezo + CP + bev 15 mg/kg (Arm B) vs CP + bev (Arm C) IV q3w for 4 or 6 cycles per investigator (INV); then maintenance atezo, atezo + bev, or bev, respectively. Co-primary endpoints were INV-assessed PFS in the ITT-WT (EGFR/ALK WT) and in WT pts with expression of a tumor T-effector gene signature (Teff-high WT) and OS in the ITT-WT. Data cutoff: 1/22/2018. Results: 349, 359, and 337 ITT-WT pts were enrolled in Arms A, B, and C, respectively, with median age 63 y, 62% male, 85% current/previous smokers, and 42% ECOG PS 0. With 13.5 mo min FU, OS was improved in Arm B vs C (HR, 0.78 [95% CI: 0.64, 0.96]; P = 0.016) in the ITT-WT; populations of interest are shown in the Table. Arm A vs C OS HR was 0.88 (95% CI: 0.72, 1.08; P = 0.204). In all treated patients, Gr 3-4 treatment-related AEs occurred in 43%, 57%, and 49% of pts in Arms A, B, and C, respectively. Conclusions: IMpower150 showed a significant OS benefit with atezo + CP + bev vs CP + bev in 1L NSQ NSCLC, and no new safety signals were seen. Clinical trial information: NCT02366143 IC, tumor-infiltrating immune cells; NE, not estimable; TC, tumor cells. a WT excludes pts with EGFR or ALK genomic alterations. b Present at baseline. TC1/2/3 or IC1/2/3 = PD-L1+ ≥ 1% of TC or IC; TC0 and IC0 = PD-L1+ < 1% of TC and IC

Arm B vs C OS in populations of interest.

PopulationNo. of PtsHR (95% CI)mOS, mo
Arm BArm C
ITT-WTa6960.78 (0.64, 0.96)19.214.7
ITT8000.76 (0.63, 0.93)19.814.9
EGFR/ALK+1040.54 (0.29, 1.03)NE17.5
Liver metastasesb940.54 (0.33, 0.88)13.29.1
Subgroups in ITT-WT
TC1/2/3 or IC1/2/33570.77 (0.58, 1.04)22.516.4
TC0 and IC03390.82 (0.62, 1.08)17.114.1
Teff-high2850.83 (0.59, 1.17)25.016.7
Teff-low3770.78 (0.60, 1.02)17.614.3

Other Abstracts in this Sub-Category:


1. Pembrolizumab (pembro) versus platinum-based chemotherapy (chemo) as first-line therapy for advanced/metastatic NSCLC with a PD-L1 tumor proportion score (TPS) ≥ 1%: Open-label, phase 3 KEYNOTE-042 study.

Meeting: 2018 ASCO Annual Meeting Abstract No: LBA4 First Author: Gilberto Lopes
Category: Lung Cancer—Non-Small Cell Metastatic - Metastatic Non-Small Cell Lung Cancer


2. Phase 3 study of carboplatin-paclitaxel/nab-paclitaxel (Chemo) with or without pembrolizumab (Pembro) for patients (Pts) with metastatic squamous (Sq) non-small cell lung cancer (NSCLC).

Meeting: 2018 ASCO Annual Meeting Abstract No: 105 First Author: Luis G. Paz-Ares
Category: Lung Cancer—Non-Small Cell Metastatic - Metastatic Non-Small Cell Lung Cancer


3. A comparative clinical study of PF-06439535, a candidate bevacizumab biosimilar, and reference bevacizumab, in patients with advanced non-squamous non-small cell lung cancer.

Meeting: 2018 ASCO Annual Meeting Abstract No: 109 First Author: Mark A. Socinski
Category: Lung Cancer—Non-Small Cell Metastatic - Metastatic Non-Small Cell Lung Cancer