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2017 ASCO Annual Meeting!

Session: Translating Tumor Sequencing Into Clinical Decision-Making: The Record to Date

Type: Clinical Science Symposium

Time: Saturday June 3, 8:00 AM to 9:30 AM

Location: Hall D1

Routine molecular screening of advanced refractory cancer patients: An analysis of the first 2490 patients of the ProfilER Study.

Tumor-Based Biomarkers

Tumor Biology

2017 ASCO Annual Meeting

Abstract No:

J Clin Oncol 35, 2017 (suppl; abstr LBA100)

Author(s): Olivier Tredan, Veronique Corset, Qing Wang, Romain Varnier, Camille Pacaud, Alexia Torroja, Nicolas Luppi, Monia Ezzalfani, Magali Myard, Xiaojun Jiang, Valéry Attignon, Daniel Pissaloux, Christian Baudet, Philippe Alexandre Cassier, Jérôme Fayette, Mélodie Carbonnaux, Alice Bonneville-Levard, Alain Viari, David Pérol, Jean-Yves Blay, LYric Profiler Author's Group; Département d'Oncologie Médicale, Centre Léon Bérard, Lyon, France; Centre Léon-Bérard, Lyon, France; Medical Oncology, Centre Léon Bérard, Lyon, France

Abstract Disclosures


Background: ProfiLER (NCT01774409) is a molecular profiling clinical trial exploring cancer cell genomic alterations in pts with advanced disease to guide treatment. Methods: Pts with confirmed diagnosis of advanced cancers are eligible. DNA extracted from either archival or fresh collected tumor samples was analyzed by targeted exon sequencing of 60 cancer related genes and whole genome array comparative genomic hybridization (CGH). A multidisciplinary molecular board analyzes genomic data and recommends molecular targeted therapies (MTT) when actionable alterations are found. Results: As of Jan 2017, 2490 pts (55% female, median age 59, range 1-90) were consented; 1826 (73.3%) tumors were analyzed, 301 (12%) are ongoing (not done in 363 pts (14.6%) for technical issues). Tumor types were colorectal (10.3%), gyneco (9.5%), breast (8.8%), head & neck (7.1%) carcinomas, sarcomas (7.1%) and brain tumors (6.5%). 940/1826 pts (51.5%) had at least 1 actionable mutation (AM): 579 pts with only one AM, while 358 with 2 or more AM (up to 6). Mutations (including substitutions and small indels), amplifications and homozygous deletions (HD) were observed respectively in 55.3%, 42.1% and 25.5% of tumor samples. The most common AM were on KRAS (n = 156; 8.5%), PIK3CA (n = 150; 8.2%), CDKN2A HD (n = 174; 9.5%),PTEN HD (n = 49, 2.7%), CCND1 (n = 97; 5.3%), FGFR1 (n = 56; 3.1%), MDM2 (n = 53; 2.9%), HER2 (n = 42; 2.3%) and HER1(n = 41; 2.2%). MTT were recommended in 644 pts. Among them, 101 (gyn [28%], GI [18%], breast [12%]) initiated a recommended MTT. Collection of treatment data is ongoing for 202 pts. MTT received were mTOR inhibitors (39%), anti-angiogenic TKI (21%), EGFR TKI (9.8%), inhibitors of cell cycle (6.9%). Best responses were CR (n = 2, 2.3%), PR (n = 13, 15.1%), SD (n = 29, 33.7%), PD (n = 42, 48.8%), with a median PFS of 2.8 months (95% IC: 2.2-3.5). 24% are alive progression free at 6 months. Updated data will be presented at the meeting. Conclusions: In this series of 2490 cancer pts, CGH and NGS identified actionable alterations on 51% of pts, with treatment recommendation in 35%. Most patients treated derived benefit from the recommended MTT, but these represent a minority of the whole population screened. Clinical trial information: NCT01774409

Other Abstracts in this Sub-Category:


1. Clinical application of comprehensive next generation sequencing in the management of metastatic cancer in adults.

Meeting: 2017 ASCO Annual Meeting Abstract No: 101 First Author: Erin Frances Cobain
Category: Tumor Biology - Tumor-Based Biomarkers


2. Increased CD73 and reduced IFNG signature expression in relation to response rates to anti-PD-1(L1) therapies in EGFR-mutant NSCLC.

Meeting: 2017 ASCO Annual Meeting Abstract No: 11505 First Author: Katie Streicher
Category: Tumor Biology - Tumor-Based Biomarkers


3. Genomic profiling of resistant tumor samples following progression on EGF816, a third generation, mutant-selective EGFR tyrosine kinase inhibitor (TKI), in advanced non-small cell lung cancer (NSCLC).

Meeting: 2017 ASCO Annual Meeting Abstract No: 11506 First Author: Daniel Shao-Weng Tan
Category: Tumor Biology - Tumor-Based Biomarkers