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Attend this session at the
2017 ASCO Annual Meeting!


Session: Patient and Survivor Care

Type: Oral Abstract Session

Time: Friday June 2, 3:00 PM to 6:00 PM

Location: S102

Effect of inpatient palliative care during hematopoietic stem cell transplantation (HCT) hospitalization on psychological distress at six months post-HCT.

Sub-category:
Symptom Management/Supportive Care/Palliative Care

Category:
Patient and Survivor Care

Meeting:
2017 ASCO Annual Meeting

Abstract No:
10005

Citation:
J Clin Oncol 35, 2017 (suppl; abstr 10005)

Author(s): Areej El-Jawahri, Lara Traeger, Harry VanDusen, Joseph A. Greer, Vicki A. Jackson, William F. Pirl, Jason Telles, Sarah Fishman, Alison Rhodes, Thomas R. Spitzer, Steven L. McAfee, Yi-Bin Albert Chen, Jennifer S. Temel; Massachusetts General Hospital, Boston, MA; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL; Massachusetts General Hospital and Harvard Medical School, Boston, MA

Abstract Disclosures

Abstract:

Background: Patients’ experience during HCT hospitalization leads to significant psychological distress post-HCT. Inpatient palliative care integrated with transplant care improves patient-reported QOL and symptom burden during hospitalization for HCT. We assessed the impact of the inpatient palliative care intervention on patients’ QOL, mood, and post-traumatic stress disorder (PTSD) at 6 months post-HCT. Methods: We randomized 160 patients with hematologic malignancies admitted for autologous or allogeneic HCT to an inpatient palliative care intervention (n=81) integrated with transplant care compared to transplant care alone (n=79). At baseline and 6 months post-HCT, we assessed QOL, mood, and PTSD symptoms using the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT), the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire (PHQ-9), and the PTSD checklist, respectively. To assess symptom burden during HCT hospitalization, we used the Edmonton Symptom Assessment Scale. We utilized linear regression models controlling for baseline values to analyze the intervention effects on outcomes at 6 months. We conducted causal mediation analyses to examine whether symptom burden during HCT mediated the effect of the intervention on outcomes at 6 months. Results: Between 8/14 and 1/16, we enrolled 160/186 (86%) of potentially eligible patients. At 6 months post-HCT, the intervention led to improvements in depression and PTSD symptoms, but not QOL or anxiety [Table]. Improvement in symptom burden during HCT hospitalization partially mediated the effect of the intervention on patient-reported outcomes at six months post-HCT. Conclusions: Inpatient palliative care integrated with transplant care leads to improvements in depression and PTSD symptoms at 6 months post-HCT. Addressing symptom burden during HCT hospitalization partially accounts for the effect of the intervention on these long-term outcomes. Clinical trial information: NCT02207322

β95% CIP
FACT-BMT2.72-2.96, 8.390.346
HADS-Depression-1.21-2.26, -0.160.024
HADS-Anxiety-0.61-1.69, 0.470.267
PHQ-9-1.63-3.08, -0.190.027
PTSD-4.02-7.18, -0.860.013

 
Other Abstracts in this Sub-Category:

 

1. Managing cancer and living meaningfully (CALM): A randomized controlled trial of a psychological intervention for patients with advanced cancer.

Meeting: 2017 ASCO Annual Meeting Abstract No: LBA10001 First Author: Gary Rodin
Category: Patient and Survivor Care - Symptom Management/Supportive Care/Palliative Care

 

2. SCORAD III: Randomized noninferiority phase III trial of single-dose radiotherapy (RT) compared to multifraction RT in patients (pts) with metastatic spinal canal compression (SCC).

Meeting: 2017 ASCO Annual Meeting Abstract No: LBA10004 First Author: Peter Hoskin
Category: Patient and Survivor Care - Symptom Management/Supportive Care/Palliative Care

 

3. The influence of yoga on mediational relationships between sleep and cancer-related fatigue: A URCC NCORP RCT in 321 cancer patients.

Meeting: 2017 ASCO Annual Meeting Abstract No: 10007 First Author: Po-Ju Lin
Category: Patient and Survivor Care - Symptom Management/Supportive Care/Palliative Care

 

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