2017 ASCO Annual Meeting!
Session: Patient and Survivor Care
Type: Oral Abstract Session
Time: Friday June 2, 3:00 PM to 6:00 PM
Effect of inpatient palliative care during hematopoietic stem cell transplantation (HCT) hospitalization on psychological distress at six months post-HCT.
Symptom Management/Supportive Care/Palliative Care
Patient and Survivor Care
2017 ASCO Annual Meeting
J Clin Oncol 35, 2017 (suppl; abstr 10005)
Author(s): Areej El-Jawahri, Lara Traeger, Harry VanDusen, Joseph A. Greer, Vicki A. Jackson, William F. Pirl, Jason Telles, Sarah Fishman, Alison Rhodes, Thomas R. Spitzer, Steven L. McAfee, Yi-Bin Albert Chen, Jennifer S. Temel; Massachusetts General Hospital, Boston, MA; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL; Massachusetts General Hospital and Harvard Medical School, Boston, MA
Background: Patients’ experience during HCT hospitalization leads to significant psychological distress post-HCT. Inpatient palliative care integrated with transplant care improves patient-reported QOL and symptom burden during hospitalization for HCT. We assessed the impact of the inpatient palliative care intervention on patients’ QOL, mood, and post-traumatic stress disorder (PTSD) at 6 months post-HCT. Methods: We randomized 160 patients with hematologic malignancies admitted for autologous or allogeneic HCT to an inpatient palliative care intervention (n=81) integrated with transplant care compared to transplant care alone (n=79). At baseline and 6 months post-HCT, we assessed QOL, mood, and PTSD symptoms using the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT), the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire (PHQ-9), and the PTSD checklist, respectively. To assess symptom burden during HCT hospitalization, we used the Edmonton Symptom Assessment Scale. We utilized linear regression models controlling for baseline values to analyze the intervention effects on outcomes at 6 months. We conducted causal mediation analyses to examine whether symptom burden during HCT mediated the effect of the intervention on o
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