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Attend this session at the
2017 ASCO Annual Meeting!

Session: Patient and Survivor Care

Type: Poster Session

Time: Saturday June 3, 1:15 PM to 4:45 PM

Location: Hall A

Cancer-related fatigue in breast cancer survivors: A longitudinal analysis compared to matched controls.

Psychosocial Research

Patient and Survivor Care

2017 ASCO Annual Meeting

Abstract No:

Poster Board Number:
Poster Session (Board #34)

J Clin Oncol 35, 2017 (suppl; abstr 10045)

Author(s): AnnaLynn Williams, Charles E. Heckler, Carly Lynn Paterson, Debra L. Barton, Kelley Lynn Young, Alison Katherine Conlin, Lora Rose Weiselberg, Karen Michelle Mustian, Luke Joseph Peppone, Michelle Christine Janelsins; University of Rochester Medical Center, Rochester, NY; National Cancer Institute, Rockville, MD; University of Michigan, Ann Arbor, MI; Kansas City NCORP, Kansas City, KS; Hematology and Oncology Clinic, Portland, OR; Monter Cancer Center, Lake Success, NY

Abstract Disclosures


Background: Cancer related fatigue (CRF) is commonly reported among breast cancer survivors and can negatively impact quality of life and treatment adherence. Large, prospective, longitudinal studies assessing CRF in breast cancer survivors compared to matched non-cancer controls are rare. Methods: Breast cancer survivors (n = 581, stage I-IIIBC, mean age 53.4) from community oncology clinics and age-matched controls (n = 364, mean age 52.6) completed the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI, scores range -24 to 96) prior to chemotherapy (T1), at chemotherapy completion (T2) and six-months after chemotherapy (T3). Linear mixed models compared trajectories of CRF over time in survivors compared to controls, adjusting for age, education, race, BMI, marital status, menopausal status, and depressive symptoms. Results: Survivors reported greater CRF compared to controls at all time points (mean total score T1 9.4 vs. -3.7, T2 17.0 vs. -3.3, and T3 8.5 vs. -3.1, all p < 0.001; all subscales p < 0.001). From T1 to T2 survivors experienced a significant increase in CRF as shown in the total score (mean change (MC) = 8.3; effect size (ES) = 0.4 , p < 0.001), and general, mental, and physical sub-scales (MC = 4.3, 2.1, 3.2 , ES = 0.7, 0.5, 0.7, respectively, all p < 0.001), while controls experience minimal changes (MC = 0.1-0.3, ES < 0.09, p > 0.05). At T3 survivors total score returned to T1 values (MC = -0.1, ES = 0.01, p = 0.461), which was, however, still greater than controls ( p < 0.001), while general, mental, and physical CRF subscale scores remained significantly higher than T1 values (MC = 1.2, 1.7, 1.9, ES = 0.2, 0.4, 0.3, respectively, all p < 0.001; controls no change). Group by time interactions indicated changes over time were greater in the survivors than controls (p < 0.001). In multivariate analyses of survivors, age, BMI, performance status, and baseline depression significantly predicted change in CRF. Conclusions: These results from the largest well-controlled study to date showed that breast cancer survivors experience significantly more CRF prior to and after chemotherapy compared to healthy controls. Further research should aim to identify subgroups of survivors most susceptible to CRF.

Other Abstracts in this Sub-Category:


1. Web-based stress management for newly diagnosed cancer patients (STREAM): A randomized, wait-list controlled intervention study.

Meeting: 2017 ASCO Annual Meeting Abstract No: LBA10002 First Author: Viviane Hess
Category: Patient and Survivor Care - Psychosocial Research


2. Randomized trial of a cognitive-behavioral therapy mobile app for anxiety in patients with incurable cancer.

Meeting: 2017 ASCO Annual Meeting Abstract No: 10022 First Author: Joseph Greer
Category: Patient and Survivor Care - Psychosocial Research


3. Utility of the Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) in hematopoietic stem cell transplantation (HSCT).

Meeting: 2017 ASCO Annual Meeting Abstract No: 10046 First Author: Patricia B. Mumby
Category: Patient and Survivor Care - Psychosocial Research